APPROVED USE

NULOJIX® (belatacept) is a prescription medicine used to prevent transplant rejection in adults who have received a kidney transplant. NULOJIX, an intravenous infusion, is used with corticosteroids and certain other medicines.

  • It is not known if NULOJIX is safe and effective in children under 18 years old or in people who receive any other organ transplant
  • NULOJIX should only be used in people who have been exposed to the Epstein-Barr virus

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Pricing
Information

NULOJIX intravenous (IV) infusion

Like many patients, knowing what you may pay for treatment can be a major concern. That’s why Bristol-Myers Squibb (BMS) is committed to helping you understand your out-of-pocket (OOP) costs and possible resources that may help make them more affordable.

For patients receiving NULOJIX during the initial dose phase, the list price for an infusion of 4 (four) vials is $3,785.* During the maintenance phase, the list price for an infusion of 2 (two) vials is $1,892.* Most patients will pay less for NULOJIX.

NULOJIX Costs by Type of Insurance:

  • If you have Commercial Insurance

    If you are commercially insured and qualify for the co-pay program, you may pay as little as $50 per infusion. This price does not include the cost of administration. Restrictions apply. Please click here for Terms and Conditions.

  • If you have Medicare

    If you have Medicare, you may pay $0 to $757 per infusion during the initial dosing phase, and $0 to $378 per infusion during the maintenance dosing phase. Your costs are determined by your medical coverage such as Medicare Part B, Medicare Advantage (Part C), as well as whether you have supplemental or Medigap coverage. More than 75% of Medicare patients have Medicare Advantage or Medicare Part B with supplemental coverage that would reduce their cost of infused medication. Use this link to learn about Medigap or Supplemental Coverage.

  • If you have Medicaid

    If you have Medicaid, you may pay $0 to $20 per infusion. To find out if you qualify for Medicaid, or to get more information about co-payments in your state, please use this link to visit the Medicaid website.

  • If you do not have insurance coverage

    If you do not have medical coverage or your insurance does not cover NULOJIX, you may pay the list price shown above with additional administration fees or discounts from your healthcare provider.

    We can help you and your healthcare provider find out what your costs may be. Please ask your doctor, visit BMS Access Support, or call BMS Access Support at , 8 AM to 8 PM ET, Monday to Friday.

  • The BMS Access Support® program provides resources to help patients understand their insurance coverage and find information on sources of financial support.

    As part of the BMS Access Support program, the BMS Kidney Transplant Co-Pay Assistance Program may help eligible commercially insured patients pay as little as $50 per infusion. The program covers up to a maximum of $7,000 in co-pays per calendar year.

    To learn more, please ask your doctor, visit BMS Access Support, or call BMS Access Support at , 8 AM to 8 PM ET, Monday to Friday.

*For NULOJIX, there is an initial dose phase which is followed by a maintenance dose phase. The initial dose phase begins the day of transplant (day 1) and then 4 days, 2 weeks, 4 weeks, 8 weeks and 12 weeks after the transplant. After the initial dose phase, NULOJIX will be continued every 4 weeks during the maintenance phase. The number of 250-mg vials received per infusion may vary, based on the patient's weight, dose phase and treatment plan. The list prices above are as of January 2019. List price is also known as wholesale acquisition cost or WAC. WAC is the price at which pharmaceutical manufacturers sell their products to wholesalers. Most people do not pay the list price for NULOJIX. List prices for infusion are for the cost of drug and do not include administration fees.

The BMS Kidney Transplant Co-Pay Assistance Program may help eligible commercially insured patients pay as little as $50 per infusion. The program covers up to a maximum of $7,000 in co-pays per calendar year. See Terms and Conditions.

Source: An Overview of Medicare, Kaiser Family Foundation, February 13, 2019. https://www.kff.org/medicare/issue-brief/an-overview-of-medicare/.

SELECTED IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NULOJIX® (belatacept)?

NULOJIX increases your risk of serious side effects, including:

Post-transplant lymphoproliferative disorder (PTLD), a condition that can happen if certain white blood cells grow out of control because of a weakened immune system.

  • PTLD can worsen, become a type of cancer, and can lead to death
  • NULOJIX increases the risk of getting PTLD; if you get PTLD with NULOJIX, you are at especially high risk of PTLD in your brain
  • Your risk for PTLD is also higher if you:
    • have never been exposed to the Epstein-Barr virus (EBV). Your doctor will test you for EBV exposure. Do not receive NULOJIX unless you are EBV positive (you have been exposed to EBV)
    • get an infection with cytomegalovirus (CMV)
    • receive treatment for transplant rejection that lowers certain white blood cells (T cells)

Other cancers, including skin cancer due to a weakened immune system.

  • Limit the amount of time you spend in sunlight, wear protective clothing, use sunscreen with a high SPF, and avoid using tanning beds or sunlamps

Progressive multifocal leukoencephalopathy (PML), a rare, serious brain infection caused by JC virus due to a weakened immune system.

  • PML can result in death or severe disability
  • There is no known prevention, treatment, or cure for PML

Other serious infections, including tuberculosis (TB) and infections caused by bacteria, viruses, or fungi.

  • These serious infections may lead to death
  • The BK virus can affect how your kidney works and cause your transplanted kidney to fail

Tell your doctor right away if you get any of these symptoms during treatment with NULOJIX:

  • Change in mood or your usual behavior
  • Confusion or problems with thinking or memory
  • Change in the way you walk or talk
  • Decreased strength or weakness on one side of your body
  • Change in vision
  • Fever, night sweats, or tiredness that does not go away
  • Weight loss
  • Swollen glands
  • Flu, cold symptoms, or cough
  • Stomach-area pain
  • Vomiting or diarrhea
  • Tenderness over transplanted kidney
  • Change in amount of urine that you make, blood in your urine, pain, or burning upon urination
  • New skin lesion or bump, or change in size or color of a mole

Liver transplant patients should not receive NULOJIX due to increased risk of loss of transplanted liver and death.

What should I tell my doctor before receiving NULOJIX?
Before receiving NULOJIX, tell your doctor if you:

  • Plan to receive any vaccines
    • Avoid receiving live vaccines during treatment with NULOJIX
    • Some vaccines may not work as well while you are receiving NULOJIX
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant
    • It is not known if NULOJIX will harm your unborn baby
    • If you become pregnant while taking NULOJIX, tell your doctor right away. You and your doctor should decide if you will keep taking NULOJIX while pregnant
  • Are breast-feeding or plan to breast-feed
    • It is not known if NULOJIX passes into your breast milk
    • You and your doctor should decide if you will take NULOJIX or breast-feed. You should not do both

Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Do not take any new medicine without talking with your transplant doctor first. Take all the medicines prescribed by your doctor to prevent infection or transplant rejection.

What are other possible side effects of NULOJIX® (belatacept)?

  • Low red blood count (anemia)
  • Diarrhea
  • Kidney or bladder infection
  • Swollen legs, feet, or ankles
  • Constipation
  • High blood pressure
  • Fever
  • New kidney not working well
  • Cough
  • Nausea or vomiting
  • Headache
  • Low or high potassium in your blood
  • Low white blood cell count

Tell your doctor about any side effect that bothers you or that does not go away. These are not all the possible side effects of NULOJIX. For more information, ask your doctor or pharmacist.

Please see Full Prescribing Information, including “What is the most important information I should know about NULOJIX?” in the Medication Guide.